Autoinflammatory diseases: a possible cause of thrombosis?

Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder, whose causing gene (MeFV gene) was identified in 1997 and opened the way to a new fascinanting chapter of rheumatology. A growing body of monogenic and poligenic autoinflammatory disorders has been described since then. Arterial and venous thrombosis is a common medical problem, with significant morbidity and mortality. Strong evidences from basic research and clinical epidemiological studies support the theory that inflammation and thrombosis can be associated. Because of their recurrent/chronic inflammatory nature, autoinflammatory diseases are a putative cause of thrombotic manifestations. In the present work, we reviewed the available evidences about monogenic autoinflammatory disorders, complicated by thrombotic manifestations

Clinical hints to diagnosis of attenuated forms of Mucopolysaccharidoses

The mucopolysaccharidoses (MPS) are clinically similar but also heterogeneous in terms of major or minor involvement of different organs/systems, burden of disease, and rate of progression. The attenuated forms of MPS, due to their less severe presentations, are more difficult to diagnose and often receive a significantly delayed diagnosis. On the other hand, the diagnosis is very important since the attenuated forms may benefit from earlier treatments. The aim of this paper is to describe the natural history and the clinical signs useful to arise a suspicion of an attenuated form of MPS. MPS patients usually show a cluster of signs and symptoms, one of which may be the trigger for an evaluation by a specialist. Individuals with attenuated MPS are mostly cognitively normal, and dysmorphisms of the facies may be mild or absent. The most frequently involved organs/systems are the osteoarticular system, heart, and eyes. These patients may also have hepatosplenomegaly, hearing loss, and respiratory problems. When they are referred to a specialist (rheumatologist, cardiologist, ophthalmologist, surgeon, orthopedist, etc.) for their main complaint, the other signs and symptoms are likely to be missed in the medical history. To avoid missing data and to save time, we propose a semistructured medical history form to be filled in by the patients or their caregivers while waiting for evaluation by a specialist

La “ricezione acustica” della direttiva shareholder rights II in Italia. Spunti di riflessione

The implementation in Italy of the EU Directive no. 2017/828 (so-called Shareholder Rights Directive II), by means of the Legislative Decree no. 49 dated 10 May 2019, meant to encourage the long-term engagement of shareholders of listed companies, by juxtaposing several legal issues with the aim of converging towards a better effectiveness of corporate governance. In particular, a specific focus is devoted to the need for an active and conscious participation of shareholders, favouring the engagement of institutional investors and asset managers. In addition, in order to protect the exercise of the right to vote by shareholders from any conflicts of interest, high standards of transparency on proxy advisors are introduced. Finally, directors’ remuneration and related party transactions are also addressed so as to avoid abuses by the management that could negatively affect the profitability of the company. This article analyses the objectives pursued by the Directive and then focuses on the Italian implementation thereof, showing the lack of consistency between the policy goals pursued and the means actually adopted by the Italian legislator

The Archaeo-Term Project: Multilingual Terminology in Archaeology

In this paper, we present the Archaeo-Term Project, along with one of its first efforts in enhancing multilingual access to Archaeological data, making available a resource of Archaeological terms within the framework of YourTerm CULT project. In order to enhance and promote the use of a terminological common ground across different languages the Archaeo-Term multilingual Glossary is intended both for scholars, experts in the field, translators and the general public. Its first release contains terms in Italian, English, German, Spanish and Dutch together with PoS, definitions and other linguistic information. This paper presents the data and the methodology adopted to create the glossary as well as the evaluation of the first results

Monitoring Social Media to Identify Environmental Crimes through NLP - A Preliminary Study

This paper presents the results of research carried out on the UNIOR Eye corpus, a corpus which has been built by downloading tweets related to environmental crimes. The corpus is made up of 228,412 tweets organized into four different subsections, each one concerning a specific environmental crime. For the current study we focused on the subsection of waste crimes, composed of 86,206 tweets which were tagged according to the two labels alert and no alert. The aim is to build a model able to detect which class a tweet belongs to